Price, C.H., D.J. McAdoo, R.E. Coggeshall and T.M. Iliffe. 1978.
Identified Aplysia neurons with rapid and specific glycine uptake.
In: Amino Acids as Chemical Transmitters, F. Fornim,
ed., Plenum Publishing Corp., New York,
pp. 213-219.
Glycine concentrations in individual cell bodies of the
identified giant neurons R3-R14 in the parietovisceral ganglion of the mollusc
Aplysia californica are up to 20 times higher than in neighboring neurons
(Iliffe et al., 1977). High concentrations of putative
neurotransmitters are present in invertebrate neurons thought to use those
compounds as transmitters (Otsuka et al., 1967; Rude et al., 1969;
McCamen et al.; Weinreich et al., 1973). In vertebrates,
relatively high concentrations of glycine are present in the ventral grey matter
of the spinal cord (Aprison et al., 1975), where glycine is probably used
as an inhibitory neurotransmitter, particularly since other putative
transmitters have not been found in these neurons (Cottrell, 1974; McCaman et
al., 1976) Because specific uptake systems for probable
neurotransmitters frequently exist (Kuhar, 1973; Hokfelt and Ljungdahl,
1975; Iverson 1975), we undertook a biochemical and autoradiographic study
of glycine uptake into cell bodies of R3-R14 and other Aplysia
neurons.
C.H. Price, D.J. McAdoo,
R.E. Coggeshall, and T.M. Iliffe, Marine Biomedical Institute, Department of
Human Biochemistry and Genetics, And Department of Anatomy, University of
Texas Medical Branch, Galveston, TX, 77550, USA.
E-mail:
iliffet@tamug.edu
Keywords:
Aplysia; glycine; neurotransmitter; neurons.
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